Infiltrated IL-17A-producing gamma delta T cells play a protective role in sepsis-induced liver injury and are regulated by CCR6 and gut commensal microbes

Introduction Sepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play protective role sepsis. However, the function and mechanism of γδ sepsis-induced injury not been fully elucidated. IL-17A-producing are newly identified cell subtype. Methods We utilized IL-17A-deficient mice to investigate sepsis using cecum ligation puncture (CLP) model. Results Our findings suggested these were major source IL-17A protected against Flow cytometry analysis revealed expressed Vγ4 TCR migrated into from peripheral post CLP, CCR6-dependent manner. When CLP treated with anti-CCR6 antibody block CCR6-CCL20 axis, recruitment Vγ4+ was abolished, indicating manner migration. Interestingly, pseudo germ-free antibiotics showed hepatic IL-17A+ regulated by gut commensal microbes. E. coli alone able restore effect rescuing population. Conclusion research has shown infiltrating crucial protecting This protection contingent upon CCR6